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27 April 2015 Bridging molecular and cellular biology with optics (Presentation Video)
Gabriel Popescu
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Proceedings Volume 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII; 933902 (2015) https://doi.org/10.1117/12.2179067
Event: SPIE BiOS, 2015, San Francisco, California, United States
Abstract
Understanding the structure and function of living cells from the nano to the micron scale remains a grand challenge. While X-ray diffraction and electron microscopy reveal nanoscale information from cellular structures, they operate with lifeless specimens. By contrast, optical techniques are well suitable for studying live cells. However, the resolution of the far-field “linear” microscopy is approximately 300 nm, a manifestation of Heisenberg’s uncertainty relation. Thus, pushing the biophotonics investigation toward the molecular scale is faced with significant challenges but also with unique opportunities. We will describe various principles dedicated to this goal and present some recent advances in phase sensitive measurements.
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Gabriel Popescu "Bridging molecular and cellular biology with optics (Presentation Video)", Proc. SPIE 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII, 933902 (27 April 2015); https://doi.org/10.1117/12.2179067
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KEYWORDS
Molecular biology
Biomedical optics
Video
Biology
Cell biology
Phase measurement
Electron microscopy
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