New method to detect organic nanoparticles in live tissue

Dror Fixler; Inbar Yariv

doi:10.1117/12.2076109

12 March 2015 New method to detect organic nanoparticles in live tissue

Dror Fixler, Inbar Yariv

Proceedings Volume 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII; 93390R (2015) https://doi.org/10.1117/12.2076109
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

In recent years, infiltrating materials into the human body has become a great challenge many researches are facing. In medicine and cosmetics today, there are materials which are administrated to patients by injection only. The main challenge with topical medication is penetrating the skin barrier. The skin is an effective barrier between the body and the outside environment, which prevents foreign materials entering the body easily. However, reducing the size of the desired materials might help their skin penetration ability. Recently nanoparticles (NPs) are being evaluated for use in many fields like chemistry, biology, medicine, physics and optics. The technique used in this work for forming organic NPs (ONPs) is the application of sonic waves to an aqueous solution, known as sonochemistry. To investigate the physical penetration depth of ONPs into the human body, we first developed a novel optical technique for detecting NPs within tissues. The detection of NPs is done by the extraction and investigation of the reemitted light phase.

Citation Download Citation

Dror Fixler and Inbar Yariv "New method to detect organic nanoparticles in live tissue", Proc. SPIE 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII, 93390R (12 March 2015); https://doi.org/10.1117/12.2076109

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