11 March 2015 DNA origami based assembly of gold nanoparticle dimers for SERS detection
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Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 934002 (2015) https://doi.org/10.1117/12.2076799
Event: SPIE BiOS, 2015, San Francisco, California, United States
Plasmonic sensors are extremely promising candidates for label-free single molecule analysis but require exquisite control over the physical arrangement of metallic nanostructures. We employ self-assembly based on the DNA origami technique for accurate positioning of individual 40 nm gold nanoparticles with gaps of 3.3±1 nm. This is probed through far field scattering measurements on individual dimers. This plasmonic coupling allows us to use surface enhanced Raman scattering (SERS) to detect a small number of dye molecules as well as short single-stranded DNA oligonucleotides in the vicinity of the dimers. This demonstrates that DNA origami is a powerful tool with great potential for a wide variety of biosensing and single-molecule applications.
© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Vivek V. Thacker, Vivek V. Thacker, Lars O. Herrmann, Lars O. Herrmann, Daniel O. Sigle, Daniel O. Sigle, Tao Zhang, Tao Zhang, Tim Liedl, Tim Liedl, Jeremy J. Baumberg, Jeremy J. Baumberg, Ulrich F. Keyser, Ulrich F. Keyser, "DNA origami based assembly of gold nanoparticle dimers for SERS detection", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934002 (11 March 2015); doi: 10.1117/12.2076799; https://doi.org/10.1117/12.2076799

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