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11 March 2015 Stamping SERS for creatinine sensing
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Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 934004 (2015)
Event: SPIE BiOS, 2015, San Francisco, California, United States
Urine can be obtained easily, readily and non-invasively. The analysis of urine can provide metabolic information of the body and the condition of renal function. Creatinine is one of the major components of human urine associated with muscle metabolism. Since the content of creatinine excreted into urine is relatively constant, it is used as an internal standard to normalize water variations. Moreover, the detection of creatinine concentration in urine is important for the renal clearance test, which can monitor the filtration function of kidney and health status. In more details, kidney failure can be imminent when the creatinine concentration in urine is high. A simple device and protocol for creatinine sensing in urine samples can be valuable for point-of-care applications. We reported quantitative analysis of creatinine in urine samples by using stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) based SERS substrate. S-SERS technique enables label-free and multiplexed molecular sensing under dry condition, while NPGD provides a robust, controllable, and high-sensitivity SERS substrate. The performance of S-SERS with NGPDs is evaluated by the detection and quantification of pure creatinine and creatinine in artificial urine within physiologically relevant concentration ranges.
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Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Greggy M. Santos, Chandra Mohan, and Wei-Chuan Shih "Stamping SERS for creatinine sensing", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934004 (11 March 2015); doi: 10.1117/12.2078530;

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