11 March 2015 An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events
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Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 93400O (2015) https://doi.org/10.1117/12.2076915
Event: SPIE BiOS, 2015, San Francisco, California, United States
Abstract
We report a versatile nanophotonic biosensing platform that enables both colorimetric detection and enhanced Raman spectroscopy detection of molecular binding events. Through the integration of electron-beam lithography, dip-pennanolithography and molecular self-assembly, we demonstrate plasmonic nanostructures which change geometry and plasmonic properties in response to molecularly-mediated nanoparticle binding events. These biologically-active nanostructured surfaces hold considerable potential for use as multiplexed sensor platforms for point-of-care diagnostics, and as scaffolds for a new generation of molecularly dynamic metamaterials.
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Esmaeil Heydari, David Thompson, Duncan Graham, Jonathan M. Cooper, Alasdair W. Clark, "An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 93400O (11 March 2015); doi: 10.1117/12.2076915; https://doi.org/10.1117/12.2076915
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