18 March 2015 Small animal lung imaging with an in-line X-ray phase contrast benchtop system
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We present the results from a benchtop X-ray phase-contrast (XPC) method for lung imaging that represents a paradigm shift in the way small animal lung imaging is performed. In our method, information regarding airway microstructure that is encoded within speckle texture of a single XPC radiograph is decoded to spatially resolve changes in lung properties such as microstructure sizes, air volumes, and compliance, to name a few. Such functional information cannot be derived from conventional lung radiography or any other 2D imaging modality. By computing these images at different time points within a breathing cycle, dynamic functional imaging can be potentially achieved without the need for tomography.
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A. B. Garson, A. B. Garson, S. Gunsten, S. Gunsten, H. Guan, H. Guan, S. Vasireddi, S. Vasireddi, S. Brody, S. Brody, M. A. Anastasio, M. A. Anastasio, "Small animal lung imaging with an in-line X-ray phase contrast benchtop system", Proc. SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94120L (18 March 2015); doi: 10.1117/12.2082898; https://doi.org/10.1117/12.2082898


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