18 March 2015 Initial results from a prototype whole-body photon-counting computed tomography system
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X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.
© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Z. Yu, S. Leng, S. M. Jorgensen, Z. Li, R. Gutjahr, B. Chen, X. Duan, A. F. Halaweish, L. Yu, E. L. Ritman, C. H. McCollough, "Initial results from a prototype whole-body photon-counting computed tomography system", Proc. SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94120W (18 March 2015); doi: 10.1117/12.2082739; https://doi.org/10.1117/12.2082739


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