In this paper, we propose a strategy to perform high spatial resolution MR imaging of the hippocampus and insula with 3T scanners that enables accurate contrast (no systematic bias) and arbitrarily high SNR. This requires the collection of additional repeated measurements of the same image and a proper averaging of the k-space data in the complex domain. This comes at the cost of additional scan time, but long single-session scan times are not practical for obvious reasons. Hence, we also develop an approach to combine k-space data from multiple sessions, which enables the total scan time to be split into arbitrarily short sessions, where the patient is allowed to move and rest in-between. For validation, we hereby illustrate our multi-session complex averaging strategy by providing high spatial resolution 3T MR visualization of the hippocampus and insula using an ex-vivo specimen, so that the number of sessions and the duration of each session are not limited by physiological motion or poor subject compliance.
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Aymeric Stamm, Jolene M. Singh, Benoit Scherrer, Onur Afacan, Simon K. Warfield, "Multi-session complex averaging for high resolution high SNR 3T MR visualization of ex vivo hippocampus and insula," Proc. SPIE 9413, Medical Imaging 2015: Image Processing, 941328 (20 March 2015);