Automatic diagnosis of inflammatory muscle disease for MRI using computer-extracted features of bivariate histograms

James Jack; Terence Jones; Charles Hutchinson; Helmut Bez; Eran Edirisinghe

doi:10.1117/12.2076757

20 March 2015 Automatic diagnosis of inflammatory muscle disease for MRI using computer-extracted features of bivariate histograms

James Jack, Terence Jones, Charles Hutchinson, Helmut Bez, Eran Edirisinghe

Author Affiliations +

Proceedings Volume 9414, Medical Imaging 2015: Computer-Aided Diagnosis; 941402 (2015) https://doi.org/10.1117/12.2076757
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

Inflammatory muscle disease is a group of rare idiopathic conditions that cause progressive skeletal muscle weakness. Diagnosis typically requires an assortment of clinical tests, including magnetic resonance imaging (MRI) of the thigh muscles to assess fat infiltration and inflammation. We hypothesise that features from multi-spectral MRI can accurately predict patient diagnosis, without the need for additional tests. A novel method is presented using computer-extracted features of the T1-STIR bivariate histogram to detect disease. The dataset comprised of 78 image-pairs from 8 patients with inflammatory muscle disease symptoms and 61 image-pairs from 9 control cases with no disease. T1 and STIR slices were co-registered and the background discarded. A feature vector was designed to measure the distribution of standardised intensity values (e.g. standard deviation, kurtosis, gini) for the muscle, fat, and leg regions of the bivariate histogram. Feature dimensionality was reduced using a combined leave-one-out and k-folds cross-validation method to select the most important features. A Bayes network was trained to predicted patient diagnosis on a per-slice basis, 10- fold cross-validated. The system attained 92% sensitivity and 82% specificity (ROC area 0.93). These results support the hypothesis that accurate diagnosis of inflammatory muscle disease is possible using MRI alone, without the need for additional clinical tests, with the potential benefit of faster diagnosis and better care for patients with this group of rare conditions.

Citation Download Citation

James Jack, Terence Jones, Charles Hutchinson, Helmut Bez, and Eran Edirisinghe "Automatic diagnosis of inflammatory muscle disease for MRI using computer-extracted features of bivariate histograms", Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 941402 (20 March 2015); https://doi.org/10.1117/12.2076757

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available