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19 March 2015 Improved factor analysis of dynamic PET images to estimate arterial input function and tissue curves
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Factor analysis of dynamic structures (FADS) is a methodology of extracting time-activity curves (TACs) for corresponding different tissue types from noisy dynamic images. The challenges of FADS include long computation time and sensitivity to the initial guess, resulting in convergence to local minima far from the true solution. We propose a method of accelerating and stabilizing FADS application to sequences of dynamic PET images by adding preliminary cluster analysis of the time activity curves for individual voxels. We treat the temporal variation of individual voxel concentrations as a set of time-series and use a partial clustering analysis to identify the types of voxel TACs that are most functionally distinct from each other. These TACs provide a good initial guess for the temporal factors for subsequent FADS processing. Applying this approach to a set of single slices of dynamic 11C-PIB images of the brain allows identification of the arterial input function and two different tissue TACs that are likely to correspond to the specific and non-specific tracer binding-tissue types. These results enable us to perform direct classification of tissues based on their pharmacokinetic properties in dynamic PET without relying on a compartment-based kinetic model, without identification of the reference region, or without using any external methods of estimating the arterial input function, as needed in some techniques.
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Rostyslav Boutchko, Debasis Mitra, Hui Pan, William Jagust M.D., and Grant T. Gullberg "Improved factor analysis of dynamic PET images to estimate arterial input function and tissue curves", Proc. SPIE 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, 94170X (19 March 2015);

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