17 March 2015 Automated pulmonary lobar ventilation measurements using volume-matched thoracic CT and MRI
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Objectives: To develop and evaluate an automated registration and segmentation pipeline for regional lobar pulmonary structure-function measurements, using volume-matched thoracic CT and MRI in order to guide therapy. Methods: Ten subjects underwent pulmonary function tests and volume-matched 1H and 3He MRI and thoracic CT during a single 2-hr visit. CT was registered to 1H MRI using an affine method that incorporated block-matching and this was followed by a deformable step using free-form deformation. The resultant deformation field was used to deform the associated CT lobe mask that was generated using commercial software. 3He-1H image registration used the same two-step registration method and 3He ventilation was segmented using hierarchical k-means clustering. Whole lung and lobar 3He ventilation and ventilation defect percent (VDP) were generated by mapping ventilation defects to CT-defined whole lung and lobe volumes. Target CT-3He registration accuracy was evaluated using region- , surface distance- and volume-based metrics. Automated whole lung and lobar VDP was compared with semi-automated and manual results using paired t-tests. Results: The proposed pipeline yielded regional spatial agreement of 88.0±0.9% and surface distance error of 3.9±0.5 mm. Automated and manual whole lung and lobar ventilation and VDP were not significantly different and they were significantly correlated (r = 0.77, p < 0.0001). Conclusion: The proposed automated pipeline can be used to generate regional pulmonary structural-functional maps with high accuracy and robustness, providing an important tool for image-guided pulmonary interventions.
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F. Guo, F. Guo, S. Svenningsen, S. Svenningsen, E. Bluemke, E. Bluemke, Martin Rajchl, Martin Rajchl, Jing Yuan, Jing Yuan, Aaron Fenster, Aaron Fenster, Grace Parraga, Grace Parraga, "Automated pulmonary lobar ventilation measurements using volume-matched thoracic CT and MRI", Proc. SPIE 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, 941717 (17 March 2015); doi: 10.1117/12.2076398; https://doi.org/10.1117/12.2076398

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