17 March 2015 The study of photoacoustic imaging without nanoparticles as a contrast agent for anti-body drug monitoring
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Abstract
As an emerging hybrid Imaging, Photoacoustic became a powerful tool that can scan disease at the deeper site in tissue and monitor of drug delivery in vivo. PAI system used nano-particle as contrast agent to enhance the PA signal in deeper site in tissue. So this makes that PAI’s application have some limitation for monitoring of all kinds of anti-body drug, because of various anti-body’s absorption excitation. In this study, we designed a PAI system with a tunable pulse OPO laser (from 450~700nm excitation wavelength) to show the optimal wavelength for monitoring of the antibody drug; doxorubicin having peak absorption at near 500nm excitation without any nano-particle combine. We made a gelatin phantoms having 4 different concentration doxorubicin as an anti-body drug; Doxorubicin concentration were in- 0mg/ml, 0.5mg/ml, 1mg/ml, and 2mg/ml. We found that 500nm is optimization wavelength to produce PA peak signal and PAI can be tool to monitor of anti-body drug without contrast agent.
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Seung Hee Han, Seung Hee Han, Jeeun Kang, Jeeun Kang, Brian Wilson, Brian Wilson, Tai-Kyong Song, Tai-Kyong Song, Young Il Kim, Young Il Kim, } "The study of photoacoustic imaging without nanoparticles as a contrast agent for anti-body drug monitoring", Proc. SPIE 9419, Medical Imaging 2015: Ultrasonic Imaging and Tomography, 94190B (17 March 2015); doi: 10.1117/12.2082439; https://doi.org/10.1117/12.2082439
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