3 April 2015 Probe-pin device for optical neurotransmitter sensing in the brain
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Development of an optical neurotransmitter sensing device using nano-plasmonic probes and a micro-spectrometer for real time monitoring of neural signals in the brain is underway. Clinical application of this device technology is to provide autonomous closed-loop feedback control to a deep brain stimulation (DBS) system and enhance the accuracy and efficacy of DBS treatment. By far, we have developed an implantable probe-pin device based on localized field enhancement of surface plasmonic resonance on a nanostructured sensing domain which can amplify neurochemical signals from evoked neural activity in the brain. In this paper, we will introduce the details of design and sensing performance of a proto-typed microspectrometer and nanostructured probing devices for real time measurement of neurotransmitter concentrations.
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Min Hyuck Kim, Kyo D. Song, Hargsoon Yoon, Yeonjoon Park, Sang H. Choi, Dae-Sung Lee, Kyu-Sik Shin, Hak-In Hwang, Uhn Lee, "Probe-pin device for optical neurotransmitter sensing in the brain", Proc. SPIE 9434, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015, 943409 (3 April 2015); doi: 10.1117/12.2085610; https://doi.org/10.1117/12.2085610

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