3 April 2015 Probe-pin device for optical neurotransmitter sensing in the brain
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Development of an optical neurotransmitter sensing device using nano-plasmonic probes and a micro-spectrometer for real time monitoring of neural signals in the brain is underway. Clinical application of this device technology is to provide autonomous closed-loop feedback control to a deep brain stimulation (DBS) system and enhance the accuracy and efficacy of DBS treatment. By far, we have developed an implantable probe-pin device based on localized field enhancement of surface plasmonic resonance on a nanostructured sensing domain which can amplify neurochemical signals from evoked neural activity in the brain. In this paper, we will introduce the details of design and sensing performance of a proto-typed microspectrometer and nanostructured probing devices for real time measurement of neurotransmitter concentrations.
© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Min Hyuck Kim, Min Hyuck Kim, Kyo D. Song, Kyo D. Song, Hargsoon Yoon, Hargsoon Yoon, Yeonjoon Park, Yeonjoon Park, Sang H. Choi, Sang H. Choi, Dae-Sung Lee, Dae-Sung Lee, Kyu-Sik Shin, Kyu-Sik Shin, Hak-In Hwang, Hak-In Hwang, Uhn Lee, Uhn Lee, "Probe-pin device for optical neurotransmitter sensing in the brain", Proc. SPIE 9434, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015, 943409 (3 April 2015); doi: 10.1117/12.2085610; https://doi.org/10.1117/12.2085610

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