Miniaturized neural sensing and optogenetic stimulation system for behavioral studies in the rat

Min Hyuck Kim; Ilho Nam; Youngki Ryu; Laurie W. Wellman; Larry D. Sanford; Hargsoon Yoon

doi:10.1117/12.2085617

3 April 2015 Miniaturized neural sensing and optogenetic stimulation system for behavioral studies in the rat

Min Hyuck Kim, Ilho Nam, Youngki Ryu, Laurie W. Wellman, Larry D. Sanford, Hargsoon Yoon

Proceedings Volume 9434, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015; 94340B (2015) https://doi.org/10.1117/12.2085617
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2015, San Diego, California, United States

Abstract

Real time sensing of localized electrophysiological and neurochemical signals associated with spontaneous and evoked neural activity is critically important for understanding neural networks in the brain. Our goal is to enhance the functionality and flexibility of a neural sensing and stimulation system for the observation of brain activity that will enable better understanding from the level of individual cells to that of global structures. We have thus developed a miniaturized electronic system for in-vivo neurotransmitter sensing and optogenetic stimulation amenable to behavioral studies in the rat. The system contains a potentiostat, a data acquisition unit, a control unit, and a wireless data transfer unit. For the potentiostat, we applied embedded op-amps to build single potential amperometry for electrochemical sensing of dopamine. A light emitting diode is controlled by a microcontroller and pulse width modulation utilized to control optogenetic stimulation within a sub-millisecond level. In addition, this proto-typed electronic system contains a Bluetooth module for wireless data communication. In the future, an application-specific integrated circuit (ASIC) will be designed for further miniaturization of the system.

Citation Download Citation

Min Hyuck Kim, Ilho Nam, Youngki Ryu, Laurie W. Wellman, Larry D. Sanford, and Hargsoon Yoon "Miniaturized neural sensing and optogenetic stimulation system for behavioral studies in the rat", Proc. SPIE 9434, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015, 94340B (3 April 2015); https://doi.org/10.1117/12.2085617

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KEYWORDS

Optogenetics

Sensing systems

Neurotransmitters

Brain

Light emitting diodes

Electrodes

Microcontrollers

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