Measurement of diffusion coefficient of propylene glycol in skin tissue

Vadim D. Genin; Alexey N. Bashkatov; Elina A. Genina; Valery V. Tuchin

doi:10.1117/12.2180052

19 March 2015 Measurement of diffusion coefficient of propylene glycol in skin tissue

Vadim D. Genin, Alexey N. Bashkatov, Elina A. Genina, Valery V. Tuchin

Proceedings Volume 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics; 94480E (2015) https://doi.org/10.1117/12.2180052
Event: Saratov Fall Meeting 2014, 2014, Saratov, Russian Federation

Abstract

Optical clearing of the rat skin under the action of propylene glycol was studied ex vivo. It was found that collimated transmittance of skin samples increased, whereas weight and thickness of the samples decreased during propylene glycol penetration in skin tissue. A mechanism of the optical clearing under the action of propylene glycol is discussed. Diffusion coefficient of propylene glycol in skin tissue ex vivo has been estimated as (1.35±0.95)×10^-7 cm²/s with the taking into account of kinetics of both weight and thickness of skin samples. The presented results can be useful for enhancement of many methods of laser therapy and optical diagnostics of skin diseases and localization of subcutaneous neoplasms.

Citation Download Citation

Vadim D. Genin, Alexey N. Bashkatov, Elina A. Genina, and Valery V. Tuchin "Measurement of diffusion coefficient of propylene glycol in skin tissue", Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics, 94480E (19 March 2015); https://doi.org/10.1117/12.2180052

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