19 March 2015 Freeze-dried polymer-coated quantum dots for perspective biomedical application
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Abstract
Freeze-drying as known as lyophilization has been considered as a possible technique to improve the long-term stability of colloidal luminescent quantum dots (QDs) for perspective biomedical application. The paper describes synthesis of biocompatible CdSe-based core/shell QDs and discusses their optical and physical properties before and after freezedrying. Importantly, the dried nanoparticles can be stored for a long time under usual conditions and then can easily be redisperse in water at a desired concentration without such hard manipulations as sonication or heating. In this work two PEG-amine derivatives were applied for QDs pegylation: monoamine Jeffamine M1000 and diamine JeffamineED-2003. The use of different Jeffamines allows us to obtain QDs with different length of PEG chains and different ζ-potential. The influence of polymer composition on optical properties of the nanocrystals and on their stability after freeze-drying was studied.
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Valentina V. Goftman, Anna V. Gaynbuch, Elizaveta V. Panfilova, Boris N. Khlebtsov, Irina Yu. Goryacheva, "Freeze-dried polymer-coated quantum dots for perspective biomedical application", Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics, 94480X (19 March 2015); doi: 10.1117/12.2178368; https://doi.org/10.1117/12.2178368
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