19 March 2015 Mathematical model of depolarization mechanism of conducted vasoreactivity
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Abstract
We address the problem of conducted vasodilation, the phenomenon which is also known as functional hyperemia. Specifically, we test the mechanism of nondecremental propagation of electric signals along endothelial cell layer recently hypothesized by Figueroa et al. By means of functional modeling we focus on possible nonlinear mechanisms that can underlie such regenerative pulse transmission (RPT). Since endothelial cells (EC) are generally known as electrically inexcitable, the possible role of ECs in RPT mechanisms is not evident. By means of mathematical modeling we check the dynamical self-consistency of Figueroa's hypothesis, as well as estimate the possible contribution of specific ionic currents to the suggested RPT mechanism.
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Anastasiia Y. Neganova, Elena S. Stiukhina, Dmitry E. Postnov, "Mathematical model of depolarization mechanism of conducted vasoreactivity", Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics, 94481J (19 March 2015); doi: 10.1117/12.2179584; https://doi.org/10.1117/12.2179584
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