Flexible or stretchable electronic devices for healthcare technologies have attracted much attention in terms of
usefulness to assist doctors in their operating rooms and to monitor patients’ physical conditions for a long period of
time. Each device to monitor the patients’ physiological signals real-time, such as strain, pressure, temperature, and
humidity, etc. has been reported recently. However, their limitations are found in acquisition of various physiological signals simultaneously because all the functions are not assembled in one skin-like electronic system. Here, we describe a skin-like, multi-functional healthcare system, which includes single crystalline silicon nanomembrane based sensors, nanoparticle-integrated non-volatile memory modules, electro-resistive thermal actuators, and drug delivery. Smart prosthetics coupled with therapeutic electronic system would provide new approaches to personalized healthcare.