Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system

Nathan McDannold; Yongzhi Zhang; Chanikarn Power; Costas D. Arvanitis; Natalia Vykhodtseva; Margaret Livingstone

doi:10.1117/12.2178134

22 May 2015 Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system

Nathan McDannold, Yongzhi Zhang, Chanikarn Power, Costas D. Arvanitis, Natalia Vykhodtseva, Margaret Livingstone

Proceedings Volume 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII; 94670H (2015) https://doi.org/10.1117/12.2178134
Event: SPIE Defense + Security, 2015, Baltimore, MD, United States

Abstract

The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Different methods have been used to bypass the BBB, but they have limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete targets. The method presents new opportunities for the use of drugs and for the study of the brain.

Citation Download Citation

Nathan McDannold, Yongzhi Zhang, Chanikarn Power, Costas D. Arvanitis, Natalia Vykhodtseva, and Margaret Livingstone "Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system", Proc. SPIE 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII, 94670H (22 May 2015); https://doi.org/10.1117/12.2178134

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available