22 May 2015 Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system
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Abstract
The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Different methods have been used to bypass the BBB, but they have limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete targets. The method presents new opportunities for the use of drugs and for the study of the brain.
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Nathan McDannold, Nathan McDannold, Yongzhi Zhang, Yongzhi Zhang, Chanikarn Power, Chanikarn Power, Costas D. Arvanitis, Costas D. Arvanitis, Natalia Vykhodtseva, Natalia Vykhodtseva, Margaret Livingstone, Margaret Livingstone, } "Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system", Proc. SPIE 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII, 94670H (22 May 2015); doi: 10.1117/12.2178134; https://doi.org/10.1117/12.2178134
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