3 June 2015 A biosensor based on magnetic resonance relaxation
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Abstract
This work describes a biosensor based on magnetic resonance relaxation switching. The method leverages a large body of work involving nanoscale contrast agents employed in nuclear magnetic resonance (NMR) imaging. The aim was to develop a detection approach that mimics the human immune response to an invading pathogen, the release of 109 to 1012 specific antigens to guarantee quick contact with the pathogen. The technique employs magnetic nanoparticle contrast agents conjugated with specific capture agents to achieve a similar contact goal. Detection of the species involves monitoring the average relaxation time (T2) of water protons in the solution, which is highly sensitive to the concentration and distribution of the magnetic nanoparticles present. With multiple nanoparticles attaching to each individual target species their distribution will be altered, and correspondingly, the average proton relaxation time will change
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M. Sullivan, B. C. Prorok, "A biosensor based on magnetic resonance relaxation", Proc. SPIE 9488, Sensing for Agriculture and Food Quality and Safety VII, 94880B (3 June 2015); doi: 10.1117/12.2178409; https://doi.org/10.1117/12.2178409
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