13 May 2015 Sensing, capturing, and interrogation of single virus particles with solid state nanopores
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Abstract
Solid-state nanopores have gained much attention as a bioanalytical platform. By virtue of their tunable nanoscale dimensions, nanopore sensors can a spatial resolution that spans a wide range of biological species from a single-molecule to a single virus or microorganism. Several groups have already used solid-state nanopores for tag-free detection of viruses. However, no one has reported use of nanopores to capture a single virus for further interrogation by the electric field inside nanopores. In this paper we will report detection of single HIV-1 particle with solid-state nanopores and demonstrate the ability to trap a single HIV-1 particle on top of a nanopore and force it to squeeze through the pore using an electric field.
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Armin Darvish, Armin Darvish, Gaurav Goyal, Gaurav Goyal, Minjun Kim, Minjun Kim, } "Sensing, capturing, and interrogation of single virus particles with solid state nanopores", Proc. SPIE 9490, Advances in Global Health through Sensing Technologies 2015, 94900M (13 May 2015); doi: 10.1117/12.2183320; https://doi.org/10.1117/12.2183320
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