5 May 2015 Fibre tip pH sensor for tumor detection during surgery
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Abstract
Surgery on tumours commonly involves a lumpectomy method, where a section of tissue containing the tumour is removed, to improve cosmetic outcomes and quality of life. Following surgery, the margins of the removed section are checked by pathology tests to ensure that the entire tumour has been removed. Unfortunately, approximately 15-20% of margins show incomplete removal and require a subsequent operation to remove the remaining tumour. Tumour detection during surgery could allow the removed section to be enlarged appropriately, reducing the likelihood of requiring subsequent surgery. A change in the extracellular pH in the vicinity of a tumour, when compared to normal tissue, has been shown previously in literature. We have fabricated an optical fibre tip pH sensor by embedding a fluorophore within a photopolymerised acrylamide polymer on the tip of a 200 micron diameter silica fibre. Preliminary measurements of human melanoma samples have shown a significant difference in the measured pH values between tumour and normal tissue. This demonstration paves to way to highly accurate margin detection during surgery.
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Matthew R. Henderson, Matthew R. Henderson, Erik P. Schartner, Erik P. Schartner, David F. Callen, David F. Callen, P. Grantley Gill, P. Grantley Gill, Tanya M. Monro, Tanya M. Monro, } "Fibre tip pH sensor for tumor detection during surgery", Proc. SPIE 9506, Optical Sensors 2015, 950611 (5 May 2015); doi: 10.1117/12.2178825; https://doi.org/10.1117/12.2178825
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