1 June 2015 Small-volume multiparametric electrochemical detection at low cost polymeric devices featuring nanoelectrodes
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Abstract
The development of a low-cost multiparametric platform for enzymatic electrochemical biosensing that can be integrated in a disposable, energy autonomous analytical device is the target of the current work. We propose a technology to fabricate nano-electrodes and ultimately biosensors on flexible polymeric-based substrates (cyclo olefin polymer, and polyimide) using standard microfabrication (step and repeat lithography and lift-off) and rapid prototyping techniques (blade cutting). Our target is towards the fabrication of a miniaturized prototype that can work with small sample volumes in the range of 5-10μL without the need for external pumps for sample loading and handling. This device can be used for the simultaneous detection of metabolites such as glucose, cholesterol and triglycerides for the early diagnosis of diabetes.
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Maria Kitsara, Josep Maria Cirera, Miguel Aller-Pellitero, Neus Sabaté, Jaume Punter, Jordi Colomer-Farrarons, Pere Miribel-Català, F. Javier del Campo, "Small-volume multiparametric electrochemical detection at low cost polymeric devices featuring nanoelectrodes ", Proc. SPIE 9518, Bio-MEMS and Medical Microdevices II, 95180Z (1 June 2015); doi: 10.1117/12.2178908; https://doi.org/10.1117/12.2178908
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