A compact multi-wavelength optoacoustic system based on high-power diode lasers for characterization of double-walled carbon nanotubes (DWCNTs) for biomedical applications

Luca Leggio; Omar de Varona; Pedro Escudero; Guillermo Carpintero del Barrio; Marek Osiński; Horacio Lamela Rivera

doi:10.1117/12.2181021

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19 June 2015 A compact multi-wavelength optoacoustic system based on high-power diode lasers for characterization of double-walled carbon nanotubes (DWCNTs) for biomedical applications

Luca Leggio, Omar de Varona, Pedro Escudero, Guillermo Carpintero del Barrio, Marek Osiński, Horacio Lamela Rivera

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Proceedings Volume 9531, Biophotonics South America; 953114 (2015) https://doi.org/10.1117/12.2181021
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil

Abstract

During the last decade, Optoacoustic Imaging (OAI), or Optoacoustic Tomography (OAT), has evolved as a novel imaging technique based on the generation of ultrasound waves with laser light. OAI may become a valid alternative to techniques currently used for the detection of diseases at their early stages. It has been shown that OAI combines the high contrast of optical imaging techniques with high spatial resolution of ultrasound systems in deep tissues. In this way, the use of nontoxic biodegradable contrast agents that mark the presence of diseases in near-infrared (NIR) wavelengths range (0.75–1.4 um) has been considered. The presence of carcinomas and harmful microorganisms can be revealed by means of the fluorescence effect exhibited by biopolymer nanoparticles. A different approach is to use carbon nanotubes (CNTs) which are a contrast agent in NIR range due to their absorption characteristics in the range between 800 to 1200 nm. We report a multi-wavelength (870 and 905 nm) laser diode–based optoacoustic (OA) system generating ultrasound signals from a double-walled carbon nanotubes (DWCNTs) solution arranged inside a tissue-like phantom, mimicking the scattering of a biological soft tissue. Optoacoustic signals obtained with DWCNTs inclusions within a tissue-like phantom are compared with the case of ink-filled inclusions, with the aim to assess their absorption. These measurements are done at both 870 and 905 nm, by using high power laser diodes as light sources. The results show that the absorption is relatively high when the inclusion is filled with ink and appreciable with DWCNTs.

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Luca Leggio, Omar de Varona, Pedro Escudero, Guillermo Carpintero del Barrio, Marek Osiński, and Horacio Lamela Rivera "A compact multi-wavelength optoacoustic system based on high-power diode lasers for characterization of double-walled carbon nanotubes (DWCNTs) for biomedical applications", Proc. SPIE 9531, Biophotonics South America, 953114 (19 June 2015); https://doi.org/10.1117/12.2181021

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