19 June 2015 3D Monte Carlo radiation transfer modelling of photodynamic therapy
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Proceedings Volume 9531, Biophotonics South America; 95311H (2015) https://doi.org/10.1117/12.2180744
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil
Abstract
The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.
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C. Louise Campbell, C. Louise Campbell, Craig Christison, Craig Christison, C. Tom A. Brown, C. Tom A. Brown, Kenneth Wood, Kenneth Wood, Ronan M. Valentine, Ronan M. Valentine, Harry Moseley, Harry Moseley, } "3D Monte Carlo radiation transfer modelling of photodynamic therapy", Proc. SPIE 9531, Biophotonics South America, 95311H (19 June 2015); doi: 10.1117/12.2180744; https://doi.org/10.1117/12.2180744
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