19 June 2015 FT Raman spectroscopy in the study of human teeth under medications demineralization
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Proceedings Volume 9531, Biophotonics South America; 95313L (2015) https://doi.org/10.1117/12.2180782
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil
The in situ study evaluated antihistamine (DA) and bronchodilator(DB) drugs actions on dental enamel using FT Raman spectroscopy.

Analysis of pH drugs were permorfed, DA 1.48 and DB 2.90. Enamel (n=24) were analysed by FT - Raman and randomly distributed in control group (CG) and experimental groups (GEA and GEB), specimens fixed in palatine appliances. In CG, dripped 20% sucrose (8Xday/3 min)/7 days. In GEA, 20% sucrose (8Xday/3 min) + drug (4Xday/3 min). In GEB, 20% sucrose (8Xday/3 min) B + drug (4Xday/3 min). FT- Raman analysis was performed again. Data analyzed by Student t test and ANOVA

Differences in peak intensity of carbonate (CO3) /phosphate (PO4) (p<0.0286) post challenge in GEB related to baseline. The GEB integrated area of inorganic post challenge (p<0.0349).Organic loss in GEA, area (p<0.0228) and intensity (p<0. 0471) between moments and in GEB, area (p<0.0243) and intensity (p<0.00276). Comparing organic area and intensity difference observed post challenge GC (0,31±0,13) and GEB(0,54±0,13). Area difference between GEA(0,30±0,16) X GEB(0,54±0,13) and intensity difference GC(0,09172±0,04) and GEB(0,16±0,04) and GEA(0,091±0,05) X GEB(0,16±0,04). Significant integrated area CO3/PO4 loss for GC(0,12±0,01)X GEB(0,16±0,02) and GEB X GEA(0,13±0,02). For intensity differences were observed between GC(0,08±0,01) and GEB(0,10±0,01), and the last one and GEA(0,08±0,01)

After administration of drugs, reduction in the amount of carbonate, organic and inorganic components were observed, denoting possible demineralization.
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G. R. de Sant' Anna, G. R. de Sant' Anna, E. B. Nascimento, E. B. Nascimento, A. G. Higa, A. G. Higa, E. A. P. Santos, E. A. P. Santos, A. M. Espirito Santo, A. M. Espirito Santo, A. A. Martín, A. A. Martín, } "FT Raman spectroscopy in the study of human teeth under medications demineralization", Proc. SPIE 9531, Biophotonics South America, 95313L (19 June 2015); doi: 10.1117/12.2180782; https://doi.org/10.1117/12.2180782

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