15 July 2015 Spectroscopic imaging of blood vessels only near the skin surface for non-invasive blood glucose measurement
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Abstract
To realize the non-invasive blood glucose measurement, it will be effective to acquire the spectroscopic imaging of blood vessels only near the skin surface for eliminating other biological-component’s disturbances. Our proposed imaging-type 2-dimensional Fourier spectroscopic imaging can limit the measuring depth into focal plane with high light detection sensitivity. Thus, the proposed method will be suitable for measuring only near the skin surface with detecting weak reflected light from inner biomembrane. But reflectance of skin surface is more than 1000 times larger than inner skin’s reflectance. Paying attention on Fresnel reflection, fingers what were illuminated by p-polarized beam from Brewster's angle were observed with crossed-Nicol dark field optics. We successfully acquired spectroscopic characteristics of hemoglobin at vein area near the skin surface.
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Masaru Fujiwara, Masaru Fujiwara, Shun Sato, Shun Sato, Pradeep K. W. Abeygunawardhana, Pradeep K. W. Abeygunawardhana, Satoru Suzuki, Satoru Suzuki, Akira Nishiyama, Akira Nishiyama, Kenji Wada, Kenji Wada, Ichiro Ishimaru, Ichiro Ishimaru, } "Spectroscopic imaging of blood vessels only near the skin surface for non-invasive blood glucose measurement", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 953714 (15 July 2015); doi: 10.1117/12.2183671; https://doi.org/10.1117/12.2183671
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