15 July 2015 In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy
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Abstract
For blood glucose level measurement of dialysis machines, we proposed AAA-battery-size ATR (Attenuated total reflection) Fourier spectroscopy in middle infrared light region. The proposed one-shot Fourier spectroscopic imaging is a near-common path and spatial phase-shift interferometer with high time resolution. Because numerous number of spectral data that is 60 (= camera frame rare e.g. 60[Hz]) multiplied by pixel number could be obtained in 1[sec.], statistical-averaging improvement realize high-accurate spectral measurement. We evaluated the quantitative accuracy of our proposed method for measuring glucose concentration in near-infrared light region with liquid cells. We confirmed that absorbance at 1600[nm] had high correlations with glucose concentrations (correlation coefficient: 0.92). But to measure whole-blood, complex light phenomenon caused from red blood cells, that is scattering and multiple reflection or so, deteriorate spectral data. Thus, we also proposed the ultrasound-assisted spectroscopic imaging that traps particles at standing-wave node. Thus, if ATR prism is oscillated mechanically, anti-node area is generated around evanescent light field on prism surface. By elimination complex light phenomenon of red blood cells, glucose concentration in whole-blood will be quantify with high accuracy. In this report, we successfully trapped red blood cells in normal saline solution with ultrasonic standing wave (frequency: 2[MHz]).
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Satsuki Hosono, Satsuki Hosono, Shun Sato, Shun Sato, Akane Ishida, Akane Ishida, Yo Suzuki, Yo Suzuki, Daichi Inohara, Daichi Inohara, Kosuke Nogo, Kosuke Nogo, Pradeep K.W. Abeygunawardhana, Pradeep K.W. Abeygunawardhana, Satoru Suzuki, Satoru Suzuki, Akira Nishiyama, Akira Nishiyama, Kenji Wada, Kenji Wada, Ichiro Ishimaru, Ichiro Ishimaru, } "In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 953715 (15 July 2015); doi: 10.1117/12.2183674; https://doi.org/10.1117/12.2183674
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