A series of in-vitro measurements were carried out to assess sufficient accuracy for monitoring of blood parameters. A vast number of blood samples with various hematological parameters, collected from different donors, were measured in order to achieve a statistical significance of results and validation of the methods. Preliminary results indicate the benefits in combination of presented complementary methods and form the basis for development of a multimodal system for rapid and accurate optical determination of selected parameters in whole human blood. Future development of optical systems and multivariate calibration models are planned to extend the number of detected blood parameters and provide a robust quantitative multi-component analysis.
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M. Gnyba, M. S. Wróbel, K. Karpienko, D. Milewska, M. Jędrzejewska-Szczerska, "Combined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometry," Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371N (15 July 2015);