Spectral fiber sensors for cancer diagnostics in vitro

V. Artyushenko; F. Schulte; U. Zabarylo; H.-P. Berlien; I. Usenov; T. Saeb Gilani; H. Eichler; Ł. Pieszczek; A. Bogomolov; H. Krause; O. Minet

doi:10.1117/12.2183949

15 July 2015 Spectral fiber sensors for cancer diagnostics in vitro

V. Artyushenko, F. Schulte, U. Zabarylo, H.-P. Berlien, I. Usenov, T. Saeb Gilani, H. Eichler, Ł. Pieszczek, A. Bogomolov, H. Krause, O. Minet

Author Affiliations +

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 953720 (2015) https://doi.org/10.1117/12.2183949
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

Cancer is one of the leading causes for morbidity and mortality worldwide. Therefore, efforts are concentrated on cancer detection in an early stage to enhance survival rates for cancer patients. A certain intraoperative navigation in the tumor border zone is also an essential task to lower the mortality rate after surgical treatment. Molecular spectroscopy methods proved to be powerful tools to differentiate cancerous and healthy tissue. Within our project comparison of different vibration spectroscopy methods were tested to select the better one or to reach synergy from their combination.

One key aspect was in special fiber probe development for each technique. Using fiber optic probes in Raman, MIR and NIR spectroscopy is a very powerful method for non-invasive in vivo applications. Miniaturization of Raman probes was achieved by deposition of dielectric filters directly onto the silica fiber end surfaces. Raman, NIR and MIR spectroscopy were used to analyze samples from kidney tumors. The differentiation between cancer and healthy samples was successfully obtained by multivariate data analysis.

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V. Artyushenko, F. Schulte, U. Zabarylo, H.-P. Berlien, I. Usenov, T. Saeb Gilani, H. Eichler, Ł. Pieszczek, A. Bogomolov, H. Krause, and O. Minet "Spectral fiber sensors for cancer diagnostics in vitro", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 953720 (15 July 2015); https://doi.org/10.1117/12.2183949

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