One key aspect was in special fiber probe development for each technique. Using fiber optic probes in Raman, MIR and NIR spectroscopy is a very powerful method for non-invasive in vivo applications. Miniaturization of Raman probes was achieved by deposition of dielectric filters directly onto the silica fiber end surfaces. Raman, NIR and MIR spectroscopy were used to analyze samples from kidney tumors. The differentiation between cancer and healthy samples was successfully obtained by multivariate data analysis.
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V. Artyushenko, F. Schulte, U. Zabarylo, H.-P. Berlien, I. Usenov, T. Saeb Gilani, H. Eichler, Ł. Pieszczek, A. Bogomolov, H. Krause, O. Minet, "Spectral fiber sensors for cancer diagnostics in vitro," Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 953720 (15 July 2015);