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15 July 2015 Non-contact high resolution Bessel beam probe for diagnostic imaging of cornea and trabecular meshwork region in eye
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Abstract
Primary angle closure glaucoma is a major form of disease that causes blindness in Asia and worldwide. In glaucoma, irregularities in the ocular aqueous outflow system cause an elevation in intraocular pressure (IOP) with subsequent death of retinal ganglion cells, resulting in loss of vision. High resolution visualization of the iridocorneal angle region has great diagnostic value in understanding the disease condition which enables monitoring of surgical interventions that decrease IOP. None of the current diagnostic techniques such as goniophotography, ultrasound biomicroscopy (UBM), anterior segment optical coherence tomography (AS-OCT) and RetCam can image with molecular specificity and required spatial resolution that can delineate the trabecular meshwork structures. This paper in this context proposes new concepts and methodology using Bessel beams based illumination and imaging for such diagnostic ocular imaging applications. The salient features using Bessel beams instead of the conventional Gaussian beam, and the optimization challenges in configuring the probe system will be illustrated with porcine eye samples.
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V. M. Murukeshan, Hong Xun Jie Jesmond, V. K. Shinoj, M. Baskaran, and Aung Tin "Non-contact high resolution Bessel beam probe for diagnostic imaging of cornea and trabecular meshwork region in eye", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 953728 (15 July 2015); https://doi.org/10.1117/12.2197417
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