16 July 2015 Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: characterization and in-vivo measurements in the 600-1350 nm spectral range
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Abstract
We report on the design, performance assessment, and first in vivo measurement of a Time-Resolved Diffuse Optical system for broadband (600-1350 nm) nm measurement of absorption and scattering spectra of biological tissues for non-invasive clinical diagnostics. Two strategies to reduce drift and enhance responsivity are adopted. The system was enrolled in a first in vivo test phase on healthy volunteers, carrying out non-invasive, in vivo quantification of key tissue constituents (oxy- and deoxy-hemoglobin, water, lipids, collagen) and tissue micro-structure (scatterer size and density).
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Sanathana Konugolu Venkata Sekar, Sanathana Konugolu Venkata Sekar, Andrea Farina, Andrea Farina, Edoardo Martinenghi, Edoardo Martinenghi, Alberto Dalla Mora, Alberto Dalla Mora, Paola Taroni, Paola Taroni, Antonio Pifferi, Antonio Pifferi, Turgut Durduran, Turgut Durduran, Marco Pagliazzi, Marco Pagliazzi, Claus Lindner, Claus Lindner, Parisa Farzam, Parisa Farzam, Mireia Mora, Mireia Mora, Mattia Squarcia, Mattia Squarcia, A. Urbano-Ispizua, A. Urbano-Ispizua, } "Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: characterization and in-vivo measurements in the 600-1350 nm spectral range", Proc. SPIE 9538, Diffuse Optical Imaging V, 95380R (16 July 2015); doi: 10.1117/12.2183835; https://doi.org/10.1117/12.2183835
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