Collagen content as a risk factor in breast cancer? A pilot clinical study

Antonio Pifferi; Giovanna Quarto; Francesca Abbate; Nicola Balestreri; Simona Menna; Enrico Cassano; Rinaldo Cubeddu; Paola Taroni

doi:10.1117/12.2183618

16 July 2015 Collagen content as a risk factor in breast cancer? A pilot clinical study

Antonio Pifferi, Giovanna Quarto, Francesca Abbate, Nicola Balestreri, Simona Menna, Enrico Cassano, Rinaldo Cubeddu, Paola Taroni

Author Affiliations +

Proceedings Volume 9538, Diffuse Optical Imaging V; 953813 (2015) https://doi.org/10.1117/12.2183618
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

A retrospective pilot clinical study on time domain multi-wavelength (635 to 1060 nm) optical mammography was exploited to assess collagen as a breast-cancer risk factor on a total of 109 subjects (53 healthy and 56 with malignant lesions). An increased cancer occurrence is observed on the 15% subset of patients with higher age-matched collagen content. Further, a similar clustering based on the percentage breast density leads to a different set of patients, possibly indicating collagen as a new independent breast cancer risk factor. If confirmed statistically and on larger numbers, these results could have huge impact on personalized diagnostics, health care systems, as well as on basic research.

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Antonio Pifferi, Giovanna Quarto, Francesca Abbate, Nicola Balestreri, Simona Menna, Enrico Cassano, Rinaldo Cubeddu, and Paola Taroni "Collagen content as a risk factor in breast cancer? A pilot clinical study", Proc. SPIE 9538, Diffuse Optical Imaging V, 953813 (16 July 2015); https://doi.org/10.1117/12.2183618

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