16 July 2015 CW fluorescence imaging of tissue-like media in reflectance geometry
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Abstract
In the present contribution we investigate images of CW diffusely remitted light registered by a CCD camera imaging a turbid medium containing an absorbent and fluorescent lesion, during illumination by a point-like source. We show that a normalization technique using local background signals reconstructed from experimental data is useful to increase the contrast of both the absorption and the fluorescence channel. Using this technique, results on phantoms are given which demonstrate that lesions with clinically-realistic fluorophore and absorber concentrations can be detected. Results are compared with theoretical calculations as well.
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N. A. Carbone, N. A. Carbone, D. I. Iriarte, D. I. Iriarte, J. A. Pomarico, J. A. Pomarico, D. Grosenick, D. Grosenick, R. Macdonald, R. Macdonald, } "CW fluorescence imaging of tissue-like media in reflectance geometry", Proc. SPIE 9538, Diffuse Optical Imaging V, 95381E (16 July 2015); doi: 10.1117/12.2183473; https://doi.org/10.1117/12.2183473
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