16 July 2015 Fiber-based hybrid probe for non-invasive cerebral monitoring in neonatology
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Abstract
Improved cerebral monitoring systems are needed to prevent preterm infants from long-term cognitive and motor restrictions. Combining advanced near-infrared diffuse spectroscopy measurement technologies, time-resolved spectroscopy (TRS) and diffuse correlation spectroscopy (DCS) will introduce novel indicators of cerebral oxygen metabolism and blood flow for neonatology. For non-invasive sensing a fiber-optical probe is used to send and receive light from the infant head. In this study we introduce a new fiber-based hybrid probe that is designed for volume production. The probe supports TRS and DCS measurements in a cross geometry, thus both technologies gain information on the same region inside the tissue. The probe is highly miniaturized to perform cerebral measurements on heads of extreme preterm infants down to head diameters of 6cm. Considerations concerning probe production focus on a reproducible accuracy in shape and precise optical alignment. In this way deviations in measurement data within a series of probes should be minimized. In addition to that, requirements for clinical use like robustness and hygiene are considered. An additional soft-touching sleeve made of FDA compatible silicone allows for a flexible attachment with respect to the individual anatomy of each patient. We present the technical concept of the hybrid probe and corresponding manufacturing methods. A prototype of the probe is shown and tested on tissue phantoms as well as in vivo to verify its operational reliability.
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Matthias Rehberger, Matthias Rehberger, Martina Giovannella, Martina Giovannella, Marco Pagliazzi, Marco Pagliazzi, Udo Weigel, Udo Weigel, Turgut Durduran, Turgut Durduran, Davide Contini, Davide Contini, Lorenzo Spinelli, Lorenzo Spinelli, Antonio Pifferi, Antonio Pifferi, Alessandro Torricelli, Alessandro Torricelli, Robert Schmitt, Robert Schmitt, } "Fiber-based hybrid probe for non-invasive cerebral monitoring in neonatology", Proc. SPIE 9538, Diffuse Optical Imaging V, 95381J (16 July 2015); doi: 10.1117/12.2197927; https://doi.org/10.1117/12.2197927
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