17 July 2015 Wavefront shaping based on three-dimensional optoacoustic feedback
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Wavefront shaping techniques have recently evolved as a promising tool to control the light distribution in optically-scattering media. These techniques are based on spatially-modulating the phase of an incident light beam to create positive interference (focusing) at specific locations in the speckle pattern of the scattered wavefield. The optimum phase distribution (mask) of the spatial light modulator that allows focusing at the target location(s) is determined iteratively by monitoring the light intensity at such target. In this regard, optoacoustic (photoacoustic) imaging may provide the convenient advantage of simultaneous feedback information on light distribution in an entire region of interest. Herein, we showcase that volumetric optoacoustic images can effectively be used as a feedback mechanism in an iterative optimization algorithm allowing controlling the light distribution after propagation through a scattering sample. Experiments performed with absorbing microparticles distributed in a three-dimensional region showcase the feasibility of enhancing the light intensity at specific points. The advantages provided by optoacoustic imaging in terms of spatial and temporal resolution anticipate new capabilities of wavefront shaping techniques in biomedical optics.
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X. Luís Deán-Ben, X. Luís Deán-Ben, Héctor Estrada, Héctor Estrada, Ali Ozbek, Ali Ozbek, Daniel Razansky, Daniel Razansky, } "Wavefront shaping based on three-dimensional optoacoustic feedback", Proc. SPIE 9540, Novel Biophotonics Techniques and Applications III, 95400K (17 July 2015); doi: 10.1117/12.2183967; https://doi.org/10.1117/12.2183967

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