Real-time optical coherence tomography observation of retinal tissue damage during laser photocoagulation therapy on ex-vivo porcine samples

P. Steiner; B. Považay; M. Stoller; P. Morgenthaler; D. Inniger; P. Arnold; R. Sznitman; Ch. Meier

doi:10.1117/12.2184013

9 July 2015 Real-time optical coherence tomography observation of retinal tissue damage during laser photocoagulation therapy on ex-vivo porcine samples

P. Steiner, B. Považay, M. Stoller, P. Morgenthaler, D. Inniger, P. Arnold, R. Sznitman, Ch. Meier

Author Affiliations +

Proceedings Volume 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media; 95410Q (2015) https://doi.org/10.1117/12.2184013
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

Retinal laser photocoagulation represents a widely used treatment for retinal pathologies such as diabetic chorioretinopathy or diabetic edema. For effective treatment, an appropriate choice of the treatment energy dose is crucial to prevent excessive tissue damage caused by over-irradiation of the retina. In this manuscript we investigate simultaneous and time-resolved optical coherence tomography for its applicability to provide feedback to the ophthalmologist about the introduced retinal damage during laser photocoagulation. Time-resolved and volumetric optical coherence tomography data of 96 lesions on ex-vivo porcine samples, set with a 577 nm laser prototype and irradiance of between 300 and 8800 W=cm² were analyzed. Time-resolved scans were compared to volumetric scans of the lesion and correlated with ophthalmoscopic visibility. Lastly, image parameters extracted from optical coherence tomography Mscans, suitable for lesion classification were identified. Results presented in this work support the hypothesis that simultaneous optical coherence tomography provides valuable information about the extent of retinal tissue damage and may be used to guide retinal laser photocoagulation in the future.

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P. Steiner, B. Považay, M. Stoller, P. Morgenthaler, D. Inniger, P. Arnold, R. Sznitman, and Ch. Meier "Real-time optical coherence tomography observation of retinal tissue damage during laser photocoagulation therapy on ex-vivo porcine samples", Proc. SPIE 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media, 95410Q (9 July 2015); https://doi.org/10.1117/12.2184013

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