9 July 2015 4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo
Author Affiliations +
Abstract
The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain during lifetime. Like all highly stressed materials, also these biological components undergo fatigue and signs of wear, which impinge upon cardiac output and in the end on health and living comfort of affected patients. Thereby pathophysiological changes of the aortic valve leading to calcific aortic valve stenosis (AVS) as most frequent heart valve disease in humans are of particular interest. The knowledge about changes of the dynamic behavior during the course of this disease and the possibility of early stage diagnosis could lead to the development of new treatment strategies and drug-based options of prevention or therapy. ApoE-/- mice as established model of AVS versus wildtype mice were introduced in an ex vivo artificially stimulated heart model. 4D optical coherence tomography (OCT) in combination with high-speed video microscopy were applied to characterize dynamic behavior of the murine aortic valve and to characterize dynamic properties during artificial stimulation. OCT and high-speed video microscopy with high spatial and temporal resolution represent promising tools for the investigation of dynamic behavior and their changes in calcific aortic stenosis disease models in mice.
© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Christian Schnabel, Christian Schnabel, Anett Jannasch, Anett Jannasch, Saskia Faak, Saskia Faak, Thomas Waldow, Thomas Waldow, Edmund Koch, Edmund Koch, } "4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo", Proc. SPIE 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media, 95410V (9 July 2015); doi: 10.1117/12.2181361; https://doi.org/10.1117/12.2181361
PROCEEDINGS
5 PAGES


SHARE
Back to Top