Gold nanoparticles decorated liposomes and their SERS performance in tumor cells

D. Zhu; Z. Y. Wang; S. F. Zong; H. Chen; P. Chen; M. Y. Li; L. Wu; Y. P. Cui

doi:10.1117/12.2182146

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4 May 2015 Gold nanoparticles decorated liposomes and their SERS performance in tumor cells

D. Zhu, Z. Y. Wang, S. F. Zong, H. Chen, P. Chen, M. Y. Li, L. Wu, Y. P. Cui

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Proceedings Volume 9543, Third International Symposium on Laser Interaction with Matter; 954316 (2015) https://doi.org/10.1117/12.2182146
Event: Third International Symposium on Laser Interaction with Matter, 2014, Jiangsu, China

Abstract

Due to their unique properties, liposomes have been widely used as drug nanocarriers. Herein a liposome-Au nanohybrid has been demonstrated as a SERS active intracellular drug nanocarrier. In this study, cationic Raman reporter tagged gold nanoparticles (Au@4MBA@PAH) were anchored onto the surfaces of anionic liposomes via electrostatic interactions. Using SKBR3 cells as model cells, we revealed that the hybrid formulation can be effectively taken up by tumor cells and tracked by the SERS signals. Collectively, the liposome-Au nanohybrids hold great promise in biomedical applications.

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D. Zhu, Z. Y. Wang, S. F. Zong, H. Chen, P. Chen, M. Y. Li, L. Wu, and Y. P. Cui "Gold nanoparticles decorated liposomes and their SERS performance in tumor cells", Proc. SPIE 9543, Third International Symposium on Laser Interaction with Matter, 954316 (4 May 2015); https://doi.org/10.1117/12.2182146

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