Real-time protein aggregation monitoring based on a simultaneous light scattering investigation and a Bloch surface wave-based approach

Sara Santi; Elsie Barakat; Reinhard Neier; Hans Peter Herzig

doi:10.1117/12.2188595

21 August 2015 Real-time protein aggregation monitoring based on a simultaneous light scattering investigation and a Bloch surface wave-based approach

Sara Santi, Elsie Barakat, Reinhard Neier, Hans Peter Herzig

Author Affiliations +

Proceedings Volume 9550, Biosensing and Nanomedicine VIII; 95500V (2015) https://doi.org/10.1117/12.2188595
Event: SPIE Nanoscience + Engineering, 2015, San Diego, California, United States

Abstract

We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid betapeptides (Aβ), linked to Alzheimer’s Disease. Here, we demonstrate the efficacy of the BSW sensor by describing a simultaneous light scattering measurement, with the purpose of real-time monitoring the size change of the Aβ aggregates, throughout fibrillization.

Conference Presentation

Citation Download Citation

Sara Santi, Elsie Barakat, Reinhard Neier, and Hans Peter Herzig "Real-time protein aggregation monitoring based on a simultaneous light scattering investigation and a Bloch surface wave-based approach", Proc. SPIE 9550, Biosensing and Nanomedicine VIII, 95500V (21 August 2015); https://doi.org/10.1117/12.2188595

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