In the nearly 60 years of spaceflight we have accomplished wonderful feats of exploration and shown the incredible spirit of the human drive to explore and understand our universe. Yet in those 60 years we have barely left our solar system with the Voyager 1 spacecraft launched in 1977 finally leaving the solar system after 37 years of flight at a speed of 17 km/s or less than 0.006% the speed of light. As remarkable as this is, we will never reach even the nearest stars with our current propulsion technology in even 10 millennium. We have to radically rethink our strategy or give up our dreams of reaching the stars, or wait for technology that does not exist. While we all dream of human spaceflight to the stars in a way romanticized in books and movies, it is not within our power to do so, nor it is clear that this is the path we should choose. We posit a technological path forward, that while not simple; it is within our technological reach. We propose a roadmap to a program that will lead to sending relativistic probes to the nearest stars and will open up a vast array of possibilities of flight both within our solar system and far beyond. Spacecraft from gram level complete spacecraft on a wafer (“wafer sats”) that reach more than ¼ c and reach the nearest star in 15 years to spacecraft with masses more than 105 kg (100 tons) that can reach speeds of near 1000 km/s such systems can be propelled to speeds currently unimaginable with our existing propulsion technologies. To do so requires a fundamental change in our thinking of both propulsion and in many cases what a spacecraft is. In addition to larger spacecraft, some capable of transporting humans, we consider functional spacecraft on a wafer, including integrated optical communications, optical systems and sensors combined with directed energy propulsion. Since “at home” the costs can be amortized over a very large number of missions. The human factor of exploring the nearest stars and exo-planets would be a profound voyage for humanity, one whose non-scientific implications would be enormous. It is time to begin this inevitable journey beyond our home.