Existing visual saliency detection methods are usually based on single image, however, without priori knowledge, the contents of single image are ambiguous, so visual saliency detection based on single image can’t extract region of interest. To solve it, we propose a novel saliency detection based on multi-instance images. Our method considers human’s visual psychological factors and measures visual saliency based on global contrast, local contrast and sparsity. It firstly uses multi-instance learning to get the center of clustering, and then computes feature relative dispersion. By fusing different weighted feature saliency map, the final synthesize saliency map is generated. Comparing with other saliency detection methods, our method increases the rate of hit.