Lab-on-Fiber biosensing for cancer biomarker detection

A. Ricciardi; R. Severino; G. Quero; B. Carotenuto; M. Consales; A. Crescitelli; E. Esposito; M. Ruvo; A. Sandomenico; A. Borriello; M. Giordano; L. Sansone; Carmine Granata; A. Cutolo; A. Cusano

doi:10.1117/12.2194943

28 September 2015 Lab-on-Fiber biosensing for cancer biomarker detection

A. Ricciardi, R. Severino, G. Quero, B. Carotenuto, M. Consales, A. Crescitelli, E. Esposito, M. Ruvo, A. Sandomenico, A. Borriello, M. Giordano, L. Sansone, Carmine Granata, A. Cutolo, A. Cusano

Author Affiliations +

Proceedings Volume 9634, 24th International Conference on Optical Fibre Sensors; 963423 (2015) https://doi.org/10.1117/12.2194943
Event: International Conference on Optical Fibre Sensors (OFS24), 2015, Curitiba, Brazil

Abstract

This work deals with a novel Lab-on-Fiber biosensor able to detect in real time thyroid carcinomas biomarkers. The device is based on a gold nanostructure supporting localized surface plasmon resonances (LSPR) directly fabricated on the fiber tip by means of electron beam lithography and lift-off process. Following a suitable chemical and biological functionalization of the sensing area, human Thyroglobulin has been detected at nanomolar concentrations. Also, compatibility with full baseline restoration, achieved through biomarkers/bioreceptors dissociation, has been demonstrated.

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A. Ricciardi, R. Severino, G. Quero, B. Carotenuto, M. Consales, A. Crescitelli, E. Esposito, M. Ruvo, A. Sandomenico, A. Borriello, M. Giordano, L. Sansone, Carmine Granata, A. Cutolo, and A. Cusano "Lab-on-Fiber biosensing for cancer biomarker detection", Proc. SPIE 9634, 24th International Conference on Optical Fibre Sensors, 963423 (28 September 2015); https://doi.org/10.1117/12.2194943

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