High sensitive reflection type long period fiber grating biosensor for real time detection of thyroglobulin, a differentiated thyroid cancer biomarker: the Smart Health project

G. Quero; R. Severino; P. Vaiano; M. Consales; M. Ruvo; A. Sandomenico; A. Borriello; M. Giordano; S. Zuppolini; L. Diodato; A. Cutolo; A. Cusano

doi:10.1117/12.2194916

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28 September 2015 High sensitive reflection type long period fiber grating biosensor for real time detection of thyroglobulin, a differentiated thyroid cancer biomarker: the Smart Health project

G. Quero, R. Severino, P. Vaiano, M. Consales, M. Ruvo, A. Sandomenico, A. Borriello, M. Giordano, S. Zuppolini, L. Diodato, A. Cutolo, A. Cusano

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Proceedings Volume 9634, 24th International Conference on Optical Fibre Sensors; 96342G (2015) https://doi.org/10.1117/12.2194916
Event: International Conference on Optical Fibre Sensors (OFS24), 2015, Curitiba, Brazil

Abstract

We report the development of a reflection-type long period fiber grating (LPG) biosensor able to perform the real time detection of thyroid cancer markers in the needle washout of fine-needle aspiration biopsy. A standard LPG is first transformed in a practical probe working in reflection mode, then it is coated by an atactic-polystyrene overlay in order to increase its surrounding refractive index sensitivity and to provide, at the same time, the desired interfacial properties for a stable bioreceptor immobilization. The results provide a clear demonstration of the effectiveness and sensitivity of the developed biosensing platform, allowing the in vitro detection of human Thyroglobulin at sub-nanomolar concentrations.

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G. Quero, R. Severino, P. Vaiano, M. Consales, M. Ruvo, A. Sandomenico, A. Borriello, M. Giordano, S. Zuppolini, L. Diodato, A. Cutolo, and A. Cusano "High sensitive reflection type long period fiber grating biosensor for real time detection of thyroglobulin, a differentiated thyroid cancer biomarker: the Smart Health project", Proc. SPIE 9634, 24th International Conference on Optical Fibre Sensors, 96342G (28 September 2015); https://doi.org/10.1117/12.2194916

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