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28 September 2015 High sensitive reflection type long period fiber grating biosensor for real time detection of thyroglobulin, a differentiated thyroid cancer biomarker: the Smart Health project
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Proceedings Volume 9634, 24th International Conference on Optical Fibre Sensors; 96342G (2015) https://doi.org/10.1117/12.2194916
Event: International Conference on Optical Fibre Sensors (OFS24), 2015, Curitiba, Brazil
Abstract
We report the development of a reflection-type long period fiber grating (LPG) biosensor able to perform the real time detection of thyroid cancer markers in the needle washout of fine-needle aspiration biopsy. A standard LPG is first transformed in a practical probe working in reflection mode, then it is coated by an atactic-polystyrene overlay in order to increase its surrounding refractive index sensitivity and to provide, at the same time, the desired interfacial properties for a stable bioreceptor immobilization. The results provide a clear demonstration of the effectiveness and sensitivity of the developed biosensing platform, allowing the in vitro detection of human Thyroglobulin at sub-nanomolar concentrations.
© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
G. Quero, R. Severino, P. Vaiano, M. Consales, M. Ruvo, A. Sandomenico, A. Borriello, M. Giordano, S. Zuppolini, L. Diodato, A. Cutolo, and A. Cusano "High sensitive reflection type long period fiber grating biosensor for real time detection of thyroglobulin, a differentiated thyroid cancer biomarker: the Smart Health project", Proc. SPIE 9634, 24th International Conference on Optical Fibre Sensors, 96342G (28 September 2015); https://doi.org/10.1117/12.2194916
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