1 July 2015 In situ and ultrasensitive DNA detection based on a graphene-coated silica fiber taper interferometer
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Proceedings Volume 9655, Fifth Asia-Pacific Optical Sensors Conference; 96551F (2015) https://doi.org/10.1117/12.2184221
Event: Fifth Asia Pacific Optical Sensors Conference, 2015, Jeju, Korea, Republic of
Abstract
A high sensitivity biosensor based on graphene coated silica fiber taper interferometer is presented. Thank to the combination of graphene coating and the optical fiber taper interferometer structure, the biosensor demonstrates improved DNA concentration sensitivity of 0.4 nm/log M and good linearity, yielding the lower detection limit of 10 pM. This high sensitivity and biocompatibility enable the biosensor in precision in-situ DNA detection, even in ultra-diluted DNA solution. Based on our work, the graphene coating could convert the concentration information of target molecular to the RI variation, and further to light signals by the taper.
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Bo Yu, Bo Yu, Yunyun Huang, Yunyun Huang, Mingfei Ding, Mingfei Ding, Yang Ran, Yang Ran, Bai-Ou Guan, Bai-Ou Guan, } "In situ and ultrasensitive DNA detection based on a graphene-coated silica fiber taper interferometer", Proc. SPIE 9655, Fifth Asia-Pacific Optical Sensors Conference, 96551F (1 July 2015); doi: 10.1117/12.2184221; https://doi.org/10.1117/12.2184221
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