22 December 2015 Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics
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Abstract
Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.
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Miguel E. Combariza, Xinghuo Yu, Warwick Nesbitt, Francisco Tovar-Lopez, Dominik G. Rabus, Arnan Mitchell, "Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics", Proc. SPIE 9668, Micro+Nano Materials, Devices, and Systems, 96681U (22 December 2015); doi: 10.1117/12.2202367; https://doi.org/10.1117/12.2202367
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