Regional river basins, transboundary rivers in particular, are shared water resources among multiple users. The tempo-spatial distribution and utilization potentials of water resources in these river basins have a great influence on the economic layout and the social development of all the interested parties in these basins. However, due to the characteristics of cross borders and multi-users in these regions, especially across border regions, basic data is relatively scarce and inconsistent, which bring difficulties in basin water resources management. Facing the basic data requirements in regional river management, the overall technical framework for remote sensing monitoring and data service system in China’s regional river basins was designed in the paper, with a remote sensing driven distributed basin hydrologic model developed and integrated within the frame. This prototype system is able to extract most of the model required land surface data by multi-sources and multi-temporal remote sensing images, to run a distributed basin hydrological simulation model, to carry out various scenario analysis, and to provide data services to decision makers.